Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial activity, it is more potent than novobiocin as a potentiator of etoposide BP-16 activity by inhibiting efflux from tumor cells.
| Molecular Formula | C22H21NO6 |
| References | Freel Meyers CL et al (2003) Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin. Biochem. 42:4179 Koinek LA and Meyer HF (1975) Novobiocic Acid synthetase. Meth. Enzymol. 43:502 Rappa G et al (2000) Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16). Oncol. Res. 12:113 |
