Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder at
CSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and liverworts, and, more surprisingly, in marine sponges and nudibranches. Polygodial has potent antibiotic, antifungal and insecticidal activity, and exhibits cytotoxic, anti-inflammatory and glucocorticoid activities. It has been reported as a plant and insect growth regulator and also possesses anti-nociceptive effects mediated via inhibition of TRPV1.
| Molecular Formula | C15H22N2 |
| References | Barnes CS and Loder JW (1962) The structure of polygodial: A new sesquiterpene dialdehyde from Polygonum hydropiper Aust. J. Chem. 15:322. Derita M et al (2013) Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies. Molecules 18:2029 Jansen BJM and de Groote AE (2004) Occurrence, biological activity and synthesis of drimane sesquiterpenoids. Nat. Prod. Rep. 21:449 Montenegro IJ et al (2013) Comparative study on the larvicidal activity of drimane sesquiterpenes and nordrimane compounds against Drosophila melanogaster til-til. Molecules 18:4192 Montenegro IJ et la (2018) Antifeedant effect of polygodial and drimenol derivatives against Spodoptera frugiperda and Epilachna paenulata and quantitative structure-activity analysis. Pest Manag. Sci. 74:1623 Robles-Kely C et al (2017) Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action. Robles-Kelly C. et al., Pestic. Biochem. Physiol. 141:50 |
