SKU: P146  / 
    CAS Number: 1810726-08-9

    Polygodial Pyridazine

    $144.06 - $504.21

    Polygodial Pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal, antiinsectan, cytotoxic, anti-inflammatory and glucocorticoid activities.

    Molecular Formula  C15H22N2

    Derita M et al (2013)  Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies. Molecules 18:2029

    Garcia DG et al (2018)  Effect of polygodial and its direct derivatives on the mammalian Na + /K + -ATPase activity. Eur. J. Pharmacol. 831:1

    Just J et al (2015)  Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis. Just J. et al., Org. Biomol. Chem. 13:11200