Polygodial Pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal, antiinsectan, cytotoxic, anti-inflammatory and glucocorticoid activities.
| Molecular Formula | C15H22N2 |
| References | Derita M et al (2013) Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies. Molecules 18:2029 Garcia DG et al (2018) Effect of polygodial and its direct derivatives on the mammalian Na + /K + -ATPase activity. Eur. J. Pharmacol. 831:1 Just J et al (2015) Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis. Just J. et al., Org. Biomol. Chem. 13:11200
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