Protoporphyrin Disodium is the disodium salt of Protoporphyrin (syn: Protoporphyrin IX, PPIX), a heterocyclic organic compound and the final intermediate in heme biosynthesis. Present in all living cells, it serves as a substrate for ferrochelatase (FECH), the final enzyme in heme production. It is a guanylate cyclase (GC) activator. It is used as a dye component in fluorescence spectroscopic characterization. The compound is used as sensitizer in photodynamic therapy and sonodynamic therapy. It can be used for photo-bleaching properties. The use of Protoporphyrin in cancer is due to its photodynamic effects.
Protoporphyrin Disodium is soluble in methanol or DMSO but practically insoluble in water.
| Molecular Formula | C34H34N4O4.Na2 |
| References |
Wang P, Wang X, Zhang K, Gao K, Song M, Liu Q. The spectroscopy analyses of PpIX by ultrasound irradiation and its sonotoxicity in vitro. Ultrasonics. 2013 Jul;53(5):935-42. doi: 10.1016/j.ultras.2012.10.019. Epub 2012 Nov 6. PMID: 23415145 Sachar M, Anderson KE and Ma X (2016) Protoporphyrin IV: The good, the bad, and the ugly. J. Pharmacol. Exp. Therapeut. 356(2):267-275 |
