Temocillin Disodium is the salt of Temocillin, a semisynthetic, β-lactamase-resistant carboxypenicillin antimicrobial. Temocillin is used as an alternative to carbapenems and is primarily effective against Gram-negative bacteria.
|Mechanism of Action||Like other β-lactams, Temocillin Disodium interferes with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBB catalyzes the pentaglycine crosslink between alanine and lysine. Without a pentaglycine crosslink, the integrity of the cell wall is compromised which leads to cell lysis and death. Temocillin is resistant to most β-lactamases, but resistance is commonly due to cells containing plasmid-encoded β-lactamases.|
Temocillin is active against several multi-resistant Gram-negative species including Salmonella typhimurium, E. coli, Haemophilus influenzae and others. In contrast, Gram-positive bacteria, bacteria with altered penicillin-binding proteins, and Pseudomonas aeruginosa are not susceptible to temocillin.
Temocillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-negative microbial isolates. Medical microbiologists use this information to recommend antibiotic treatment options. Representative MIC ranges include:
For a list of MIC values, click here.
Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am. J. Med. 103:51 PMID 9236486
Rodriguez-Villalobos H et al (2006) In vitro activity of temocillin against extended spectrum beta-lactamase-producing Escherichia coli. J Antimicrob. Chemother. 57(4):771-774 PMID 16501056
Van Landuyt HW, Pyckavet MP, Lambert A and Boelaert J (1982) In vitro activity of temocillin (BRL 17421), a novel B-lactam antibiotic. Antimicrob. Agents. Chemother. 22(4):535-540 PMID 7181470
|MIC||Burkholderia cepacia| 2 － 64|| Citrobacter diversus| 8|| Citrobacter freundii| 2 － 8|| Enterobacter cloacae| 1 － 16|| Escherichia coli| 1 － 64|| Klebsiella pneumonia| 2 － 16|| Morganella morganii | 2|| Proteus vulgaris| 1|| Serratia marcescens| 16|||