Psychotridine is the main component of an alkaloid complex isolated from Psychotria beccaroides by Lamberton and colleagues (CSIRO, Australia) in 1974. Psychotridine is structurally related to hodgkinsine. The structure of psychotridine was revised in 1999. Psychotridine is cytotoxic and inhibits platelet aggregation. Psychotridine exhibits dose-dependent analgesic activity in capsaicin-induced pain models and inhibits radioligand binding postulated to involve NMDA receptors.
| Molecular Formula | C55H62N10 |
| References |
Amador TA et al (2001) Involvement of NMDA receptors in the analgesic properties of Psychotridine. Phytomed. 8:202 Beretz A et al (1985) Polyindolinic alkaloids from Psychotria forsteriana. Potent inhibitors of the aggregation of human platelets. Planta Med. 4:300 Hart NK et al (1974) Psychotridine, a C55H62N10 alkaloid from Psychotria beccarioides (Rubaceae). Aust J Chem. 27: 639 Jannic V et al (1999) Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora. J Nat Prod. 62: 838 Roth A et al (1986) Cytotoxic activity of polyindoline alkaloids of Psychotria forsteriana (Rubiaceae). Plata Med. 6:450 |