Pyrantel (+)-Tartrate is an anthelmintic (anti-protozoal) that was first described in 1965 (Pfizer). It is effective against intestinal nematodes (roundworm, threadworm, hookworm, and nodular worm). The product is soluble in DMSO.
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| Mechanism of Action |
Pyrantel (+)-Tartrate is a nicotinic receptor agonist. It can activate nACh receptors on the body wall muscle of nematodes, causing muscle paralysis. |
| Spectrum | Anthelmintic agent |
| General Applications |
Pyrantel (+)-Tartrate is used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs). |
| Eukaryotic Cell Culture Applications |
Pyrantel Tartrate was evaluated during in vitro culture of horse dermal cell culture in which merozoites from Sarcocystic neurona were growing, the causal agent of protozoal yeloencephalitis, a neurologic disease of horses. Merozoites were exposed to a range of concentrations then plated onto dermal cell cultures. Authors found that Pyrantel Tartrate has activity against emerozoites in vitro (Kruttlin et al, 2001). |
| Molecular Formula | C11H14N2S · C4H6O6 |
| References |
Aubry ML, Cowell P, Davey MJ and Shevde S (1970) Aspects of the pharmacology of a new anthelmintic: pyrantel. Br. J. Harmacol 38(2):332-344 PMID 5417856 Kruttlin EA (2001) The effects of pyrantel tartrate on Sarcocystis neurona merozoite viability.Vet Ther. 2(3):268-276 PMID 19746670 |
