Pyrantel Pamoate is an anthelmintic (anti-protozoal) that was first described in 1965 by Pfizer. It is effective against intestinal nematodes (roundworm, threadworm, and hookworm, nodular worm, pinworm). The compound is soluble in DMSO.
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| Application | Pyrantel Pamoate is an anthelmintic (anti-protozoal). |
| Mechanism of Action | Pyrantel Pamoate is an thelmintic inhibitor of BChE, and an activator of CHRNB4. It acts as a neuromuscular blocking agent, causing contraction then paralysis. |
| Spectrum | parasites |
| Electrophoresis Applications | The synergistic effect of Pyrantel Pamoate and Metronidazole on was evaluated in the pathogenic protozoan Giardia lamblia. The in vitro effect was evaluated on its adherence to IEC-6 cells. When presented in combination, the percent adhesion was remarkable reduced, while providing low cytotoxicity to host cells (Hausen et al, 2011). |
| Molecular Formula | C11H14N2S•C23H16O6 |
| Solubility | soluble in DMSO |
| References | Aubry ML, Cowell P, Davey MJ and Shevde S (1970) Aspects of the pharmacology of a new anthelmintic: Pyrantel. Br.J.Pharmacol 38(2):332-344 PMID 5417856 Hausen MA, Menna-Barreto RF, Lira DC, de Carvalho L, Barbosa HS (2011) Synergic effect of metronidazole and pyrantel pamoate on Giardia lamblia. Parasitol Int. 60(1):54-58. PMID 20946968 Reinemeyer CR, Prado JC, Nichols EC, Marchiondo AA.(2010) Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses.Vet Parasitol. 171(1-2):111-115. PMID 20307936 |
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