Pyrazinecarboxamide, a nicotinamide analogue, is a prodrug that stops the growth of Mycobacterium tuberculosis. It is used in Mycobacterium detection kits.
| References | Raynaud C et al. “Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity. Microbiology 145.6 (1999): 1359-1367 [O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 1424] **PEER REVIEWED** Zhang Y et al. “Mechanisms of pyrazinamide action and resistance”. Microbiology Spectr. 2. 4 (2013): 1-12 |
