Pyrazinecarboxamide, a nicotinamide analogue, is a precursor compound that inhibits Mycobacterium tuberculosis. It is an antitubercular agent. It is used in Mycobacterium detection kits.
| References |
Raynaud C et al. (1999) Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity. Microbiology 145.6 (1999): 1359-1367 O'Neil, MJ (2001) The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Ed. Whitehouse Station, NJ: Merck and Co. pp. 1424 Zhang Y et al (2013) Mechanisms of pyrazinamide action and resistance. Microbiology Spectr. 2(4): 1-12 |
| Mechanism of Action |
The active moiety of pyrazinamide is Pyrazinoic Acid (POA). POA is thorugh to disrupt membrane energetics and inhbit membrane transport in M. tuberculosis. |