SKU: P128  / 
    CAS Number: 98-96-4

    Pyrazinecarboxamide

    RM349.13 - RM1,788.38

    Pyrazinecarboxamide, a nicotinamide analogue, is a precursor compound that inhibits Mycobacterium tuberculosis.  It is an antitubercular agent.  It is used in Mycobacterium detection kits.

    References

    Raynaud C et al. (1999)  Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity. Microbiology 145.6 (1999): 1359-1367

    O'Neil, MJ (2001)  The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Ed. Whitehouse Station, NJ: Merck and Co. pp. 1424

    Zhang Y et al (2013)  Mechanisms of pyrazinamide action and resistance.  Microbiology Spectr. 2(4): 1-12

    Mechanism of Action

    The active moiety of pyrazinamide is Pyrazinoic Acid (POA).  POA is thorugh to disrupt membrane energetics and inhbit membrane transport in M. tuberculosis.