Pyrrole-2-carboxylic acid is small amphoteric polar metabolite produced by many Streptomyces species, often co-produced with its dimer, pyrocoll. Pyrrole-2-carboxylic acid is an important dereplication standard in discovery, displaying a distinctive UV spectrum and a broad range of biological activities, albeit weak. More recently, pyrrole-2-carboxylic has demonstrated antiparasitic activity against Trypanosomes by selective proline racemase inhibition and has potent antifungal activity against Phytophthora.
Pyrrole-2-carboxylic acid is soluble in ethanol, methanol, DMF and DMSO.
Pyrrole-2-carboxylic acid is soluble in ethanol, methanol, DMF and DMSO.
| References | Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain. Dietera A. et al. J Antibiot. 2003, 56, 639. |
