Quetiapine Fumarate is an inhibitor of dopamine and serotonin. Serotonin is a neurotransmitter thought to play a role in depression and schizophrenia.
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|Mechanism of Action||Quetiapine Fumarate is a dibenzothiazepine with antagonist activity at dopamine (D1, D2, D3) and serotonin (5-HT1A and 5-HT2) receptors. It also antagonizes adrenoreceptors (alpha 1A, alpha 1b, alpha 2) and histamine receptor (H1).|
|Eukaryotic Cell Culture Applications||Quetiapine was found to alleviate oxidative stress in PC12 cells, leading to higher cell viability and a lower rate of apoptosis. These studies give new insight into the link between oxidative stress and pathophysiology of schizophrenia and Alzheimer's (Wang et al, 2005).|
|Molecular Formula||C21H25N3O2S · 0.5C4H4O4|
|Solubility||Slightly soluble in DMSO and DMF. slightly soluble in water.|
|References||Richelson E and Souder T (2000) Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci.68(1):29-39 PMID 11132243 Wetzel H et al (1995) Seroquel (ICI 204 636), a putative "atypical" antipsychotic, in szhizophrenia with positive symptomatology: Results of an open clinical trial and changes of neuroendocrinological and EEG parameters. Phychopharmacol 119(2):231-238 PMID 7659771 Wang H et al (2005) Olanzapine and quetiapine protect PC12 cells from B-amyloid peptide25-35-induced oxidative stress and the ensuring apoptosis. J. Neurosci. Res. 81(4):572-580|