Ribostamycin is an aminoglycoside-aminocyclitol antibiotic isolated from Streptomyces ribosidificus, originally from a soil sample in Japan. It is an important broad-spectrum antibiotic with important use against human immunodeficiency virus. Resistance to aminoglycosides is a growing concern.
Ribostamycin Sulfate is freely soluble in aqueous solution.
| Mechanism of Action | Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein. |
| Microbiology Applications | Resistance is due to bacterial enzymes that modify the structure through phosphorylation, adenylation, and acetylation and prevent the antibiotic from being able to interact with the bacterial rRNAs. |
| Spectrum | Ribostamycin is a broad-spectrum antibiotic targeting a wide range of Gram-positive and Gram- negative bacteria. |
| Molecular Formula | C17H34N4O10 · H2SO4 |
| References |
Davis BD (1987) Mechanism of bactericidal action of Aminoglycosides. Microbiol. Rev. 51.3:341-50. |
| MIC | Borrelia burgdorferi S.L.| 8 － 64|| Escherichia coli| 8 － 12.5|| |
