Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Cefetamet Sodium is the sodium salt of Cefetamet, a broad-spectrum third-generation cephalosporin antibiotic. It is classified as a 'aminothiazolyl imimomethoxy cephalosporin' since it has both methyl and...
Cefetamet is a broad-spectrum, third-generation cephalosporin antibiotic. It is classified as a 'aminothiazolyl imimomethoxy cephalosporin' since it has both methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups. The...
Tinidazole is a broad-spectrum second-generation 5-nitroimidazole antibiotic and synthetic antiprotozoal agent introduced in 1969. This imidazole derivative is used against bacteria, protozoa and parasites. The compound is similar structurally to...
Ornidazole is a nitroimidazole antibiotic and antiparasitic agent, with broad-spectrum antiprotozoan and anti-aerobic activity. It was synthsized by Hoffmann-La-Roche (1966) and was first introduced for trichomoniasis (Trichomonas vaginalis) in 1974. It...
Flomoxef Free Acid (syn: Flomoxef) is a β-lactam antibiotic, an oxa-1 cephamycin belonging to the oxacephem group. It has broad-spectrum activity against Gram-negative and Gram-positive bacteria including methicillin-resistant Staphylococcus aureus...
Secnidazole is a second-generation 5-nitroimidazole antibiotic and analog of metronidazole. It has in vitro activity against anaerobic bacteria and can be used in research for trichomoniasis, amoebiasis, giardiasis, and bacterial vaginosis. The compound...
Vaborbactam is a non-β-lactam β-lactamase inhibitor. It is synthetic biochemical based on a a cyclic boronic acid pharmacophore. It was discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. It can increase the potency of...
Ozenoxacin is a quinolone antibiotic with bacterididal activity against Staphylococcus aureus and Streptococcus pyogenes, the causal agents of impetigo. Ozenoxacin also has activity against some bacteria that are resistant to fluoroquinolones. The...
Dihydroartemisinin (syn: DHA) is a first-generation derivative of artemisinin, isolated from Artemisia annua, a traditional Chinese herb. It is the major metabolite of artemether, an antimalarial agent. DHA is used against Plasmodium falciparum, the...
Zidebactam is a non-β-lactam antibiotic that is categorized as a diabicyclooctane (DBO). It is a penicillin-binding protein 2 (PBP2) inhibitor with a high affinity for PBP2 in Gram-negative bacteria. When used in combination with cefepime, it can...
Trovafloxacin Mesylate is a broad-spectrum fluoroquinolone antibiotic. It was developed for immunology research (Pfizer). It can inhibit both Gram-positive and Gram-negative bacteria, and anaerobic organisms. The compound inhibits activity of DNA gyrase...
Ravuconazole is a triazole antifungal, a 1-butyl-1H-1,2,4- triazole. The compound has a broad-spectrum antifungal activity, and is active against molds and yeast. It has a spectrum similar to voriconazole. It inhibits cytochrome P450...
