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Actinotetraose is a unique tetrasaccharide with six tiglate esters isolated from an unidentified Amycolatopsis culture. The sugar possesses a two-fold axis of symmetry and is a co-metabolite of...
7-Aminocephalosporanic Acid (7-ACA) is a key intermediate in the production of a wide variety of semisynthetic Cephalosporin antibiotics. It is an inhibitor of bacterial (S. aureus) β-lactamase. It...
Anguinomycin A is a natural polyketide and analog of Leptomycin B, an inhibitor of protein nuclear export. It is isolated from Streptomyces spp., and displays anti-cancer activity. Anguinomycins B,...
Sch 38519 is an isochromanequinone, structurally related to lactoquinomycin. Sch 38519 inhibits thrombin-induced aggregation of human platelets and is active against Gram positive and Gram negative...
Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia...
Dihydroaeruginoic acid is a simple aromatic siderophore produced by several species of Pseudomonas. Dihydroaeruginoic acid exhibits antibacterial, antifungal and antitumor activity.Dihydroaeruginoic...
Bleomycin A5 Hydrochloride is part of the Bleomycin complex. It is an anti-neoplastic glycoprotein antibiotic used in cancer research. The Bleomycins were originally isolated for their broad...
Norcantharidin is an antitumor drug that is a modified version of the natural product antitumor drug cantharidin. Norcantharidin is demethylated, which reduces its urinary system toxicity but not its...
Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by...
Kazusamycin A is a minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin B, a nuclear export inhibitor. It is similar to...
PC-766B is a 16-membered macrolide antibiotic produced by Nocardia brasiliensis, reported by researchers at Sumitomo in 1993. Structurally, PC-766B is a member of bafilomycin class, featuring a rare...
Puromycin is an aminonucleoside antibiotic with anti-trypanosomal and antineoplastic properties. It was isolated from Streptomyces alboniger in the 1950s. Puromycin is used in cell biology to select...
