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Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens identified as an antifungal in the 1960s. Over the past 40 years, cerulenin has found broad application in...
Filipin II is a minor component of the filipin complex, a family of pentaene antifungal metabolites first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955...
Clofazimine is a unique lipophilic rhimophenazine dye with antibacterial, antimycobacterial, anti-inflammatory, immunsupressive, and antituberculosis properties. It was first synthesized in 1954 by...
Filipin III is the major component of the filipin complex, a family of pentaene antifungal metabolites first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955...
Methotrexate is a selective agent for dihydrofolate reductase (DHFR)- transfected cells, and a nucleic acid synthesis inhibitor in protein expression systems, thus can be used as an ancillary...
Caffeic Acid Phenethyl Ester (syn: CAPE) is a natural phenolic compound from honeybee hives and has demonstrated anti-carcinogenic, anti-bacterial, and antiinflammatory properties. Mechanism of...
Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides and inhibits cell proliferation and induces apoptosis in vitro.Calphostin C is soluble...
Δ2-Ivermectin B1a is an irreversible base degradation product of ivermectin found in animals treated with ivermectin and in the environment. Δ2-Ivermectin B1a is formed by rearrangement of the...
Isocyclosporin A is a rearranged degradation product formed by acid treatment of Cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC...
Metformin is a common first line antidiabetic drug, and the only FDA approved member of the biguanide drug class. More recently it has drawn attention from the cancer research sector. Several...
Lenalidomide is an analogue of the immunomodulatory drug thalidomide with increased potency and fewer adverse effects. It is used in the treatment of hematologic and solid cancers due to its...
Neochlorogenic acid is a natural polyphenol compound found primarily in fruits. Other polyphenols have proven to have a wide array of bioactivity, and already neochlorogenic acid has demonstrated...