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TS155-2 is a macrocyclic lactone related to hygrolidin but produced by a different Streptomyces species. With the exception of the original patent suggesting hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity, no literature...
UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumor activity but is devoid of antimicrobial activity.Mechanism of ActionUK-1 acts as a magnesium ion-dependent DNA binding agent and inhibitor...
Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to...
Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found...
Moxalactam Sodium (syn: Latamoxef Sodium) is a an oxacephem antibiotic usually grouped with the cephalosporins. In oxacephems such as these, the sulfur atom of the cephalosporin core is replaced with an oxygen atom. It is derived from...
Nicotinamide (Vitamin B3), USP is water-soluble amide form of Nicotinic acid. It is a poly (ADP-ribose) polymerase (PARP) inhibitor, involved in regulation of many cellular processes. It was discovered between 1935 and 1937. ...
Erythromycin is a broad-spectrum macrolide antibiotic derived from Saccharopolyspora erythraea (formerly Streptomyces erythraeus) that inhibits bacterial protein synthesis. It is composed largely of Erythromycin A, with small amounts of...
Cordycepin (syn: 3'-deoxyadenosine) is a derivative of the nucleoside adenosine which differs from adenosine in that the hydroxy group in the 3' position is replaced with hydrogen. It was originally derived from the fungus Cordyceps militaris but...
Hyaluronic Acid Sodium is the sodium salt form of Hyaluronic acid, an anionic anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is...
Cisplatin (syn: cis-diammineplatinum(II) dichloride; cis-[Pt(NH3)2Cl2), is a potent anti-tumor agent and is active against several types of solid tumors. It is a square planer coordination complex of platinum that was discovered in 1845 by Italian...
Apigenin (from Matricaria recutita) is a natural occurring, ubiquitous, low molecular weight plant flavone with low toxicity and is the most bioactive of the plant flavones. It belongs to the flavonoid subclass and has antioxidant, anticancer,...
Hydrocortisone, USP (syn: Cortisol) is a glucocorticoid steroid hormone produced in the adrenal cortex. It can be used as a supplement in culture medium for oligodendrocytes, colon cells, and epithelial cells. Hydrocortisone, USP is soluble in...
