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Cyclosporin H, EvoPure is a hydroxylated metabolite of Cyclosporin A. Cyclosporin H (M-1) and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than...
Cyclosporin A, EvoPure is a neutral, cyclic oligopeptide with immunosuppressive activity. Cyclosporin A has the most potent immunosuppressive activity of the metabolites (Cyclosporin B, C, D, E, and...
Cyclosporin D, EvoPure is a hydroxylated metabolite of Cyclosporin A. Cyclosporin D and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than Cyclosporin...
Cyclosporin C, EvoPure is a hydroxylated metabolite of Cyclosporin A. Cyclosporin C has similar immunosuppressant activity, but lower nephrotoxicity than Cyclosporin A. Cyclosporin C also has...
Cyclosporin B, EvoPure is the dihydroxylated metabolite of Cyclosporin A. Cyclosporin B (M-26) and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressive activity...
Streptozocin is an anti-tumor agent and glucosamine-nitrosourea. Streptozocin was discovered in soil microbe Streptomyces achromogenes at Upjohn (now Pfizer). It targets mammalian pancreatic islets...
Ascomycin is an ethyl analog of FK506 with strong immunosuppressant properties. Mechanism of Action Ascomycin inhibits the production of cytokines produced by Th1 and Th2 cells namely IL-2, IL-4,...
Rapamycin (Sirolimus) is a natural compound belonging to the macrolide family. It is derived from Streptomyces hygroscopicus isolated from a soil sample from Easter Island in 1972 by Mr. Sehgal of...
Colchicine is a classic mitotic inhibitor, disrupting cell division by preventing assembly of microtubules in the mitotic spindle via inhibition of tubulin polymerization. It has pleiotropic...
Doxorubicin Hydrochloride, USP is an anthracycline antibiotic and 12-hydroxylated version of daunorubicin that inhibits macromolecular biosynthesis through DNA intercalation. This chemotherapeutic...
10-Deacetyl Baccatin III (syn: 10-DAB) is a natural organic compound produced by the Pacific Yew tree. It is used as a key backbone intermediate for the semi-synthesis of Paclitaxel (Taxol), an...
Geldanamycin is a benzoquinone ansamycin antibiotic, which refers to a compound derived from ansamycin, which contain a benzene- or naphthalene-based chromophore linked by an ansa bridge and an amide...