SKU: D001  / 
    CAS Number: 23541-50-6

    Daunorubicin hydrochloride

    $105.83 - $438.62

    Daunorubicin HCl is a water soluble anthracycline chemotherapeutic agent produced by Streptomyces coeruleorubidus.

    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    Mechanism of ActionDaunorubicin acts as a polymerase inhibitor and demonstrates DNA intercalation activity which effectively inhibits cancer progress.
    Cancer ApplicationsDaunorubicin HCl has shown to be useful for treatment of acute myeloid leukemia.
    Molecular FormulaC27H29NO10 · HCl
    Solubility1mg/mL in H2O: Clear and red or orange solution
    References

    Mizuno, N.S., et al., Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. Cancer Res. 35, 1542-1546, (1975) Abstract

    Tan C, Tasaka H, Yu KP, Murphy ML, Karnofsky DA (March 1967). "Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia". Cancer 20 (3): 333–53

    Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA (April 1994). "Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells". Mol Pharmacol 45 (4): 649–56