Antitumor

Fumagillin

Fumagillin is a polyene natural product and mycotoxin isolated from Aspergillus fumigatus in 1951 as a potent antiprotozoan for agents that cause amoebiasis. More recently, Fumagillin has been shown to inhibit endothelial cell proliferation and...

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1-Alaninechlamydocin

1-Alaninechlamydocin is a cyclic tetrapeptide metabolite containing a single β-amino acid, which was isolated from a Tolypocladium sp. from the Great Lakes.  It has anti-cancer properties due to the inhibition of histone deacetylase (HDAC)...

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Diacetylcercosporin

Diacetylcercosporin is a minor hydrophobic analogue of cercosporin produced by several species of the fungal genera, Cercospora and Septoria. Diacetylcercosporin has moderate in vitro activity against Leishmania and chloroquine-sensitive strains of...

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Pyrrole-2-carboxylic acid

Pyrrole-2-carboxylic acid is small amphoteric polar metabolite produced by many Streptomyces species, often co-produced with its dimer, pyrocoll. Pyrrole-2-carboxylic acid is an important dereplication standard in discovery, displaying a distinctive UV...

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Streptonigrin

Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumor cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an...

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Cercosporin

Cercosporin (CGP049090) is a perylenequinone reported in 1957 as the causative agent of soy bean purple speck disease due to the fungal pathogen, Cercsopsorium kikuchii, which is widely found in species of Cercosporium. Cercosporin phytotoxicity is...

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Ascochlorin

Ascochlorin is an antitumor fungal metabolite with antitumor and antiviral properties.Ascochlorin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.Mechanism of ActionAscochlorin specifically inhibits matrix...

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Thiostrepton, USP

Thiostrepton is a bactericidal macrocyclic thiopeptide antibiotic that is produced by Streptomyces azureus and was originally detailed by Donovick et al. in 1955.  Thiostrepton shows broad activity against both gram-positive and gram-negative...

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Aureothricin

Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Aureothricin is a more hydrophobic...

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Zotarolimus

Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable...

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Wortmannin

Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumor and...

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Anhydroophiobolin A

3-Anhydroophiobolin A is the dehydrated analogue of ophiobolin A and is a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus Bipolaris. Like all ophiobolins, 3-anhydroophiobolin A possesses a broad...

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