Chemotherapeutics

Dacarbazine

Dacarbazine is an alkylating antineoplastic agent, a chemotherapy drug used in the treatment of numerous cancers including Hodgkin's lymphoma.Mechanism of ActionWhen converted to its active form, dacarbazine methylates the DNA base guanine at the O-6...

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Icaritin

Icaritin is a hydrolytic product of icariin, and one of the bioactive components of the epimedium genus. It has gained interest mainly from its anticancer activity, including its ability to slow the growth of cancer cells and induce apoptosis. Icaritin...

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Acalabrutinib

Acalabrutinib is a highly selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK), and is being considered for use in the treatment of relapsed chronic lymphoid leukemia. Mutations in BTK result in a variety of B-cell related malignancies, as...

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Hydroxyurea

Hydroxyurea is an antineoplastic chemotherapeutic compound used in sickle cell anemia studies and cancer research, including leukemia, skin cancer, and ovarian cancers.Hydroxyurea is freely soluble in water. Mechanism of Action Hydroxyurea...

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Ingenol-3-mebutate

Ingenol-3-mebutate is an anticancer agent isolated from Euphorbia peplus used in the treatment of Actinic keratosis. Researchers have shown interest in expanding its anticancer activity, finding promise in its ability to promote proapoptotic effects in...

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Etoposide

Etoposide is an anticancer topoisomerase inhibitor  and semisynthetic epipodophyllotoxin that was derived from the natural product podophyllotoxin extracted from the North American mayapple, Podophyllum peltatum, and the Indian species Podophyllum...

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Dabrafenib

Dabrafenib is a selective inhibitor of BRAF, a proto-oncogene. It is primarily used for the treatment of late-stage melanoma.Mechanism of ActionDabrafenib is a reversible and potent adenosine triphosphate-competitive inhibitor that selectively inhibits...

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Dasatinib

Dasatinib is multitarget kinase inhibitor used in the treatment of leukemia. Dasatinib's main targets are tyrosine kinase BCR/ABL, which works to provide the cancer cell with ATP at an uncontrolled rate causing rapid division, and the SRC family of...

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Imatinib Mesylate

Imatinib mesylate is a tyrosine kinase inhibitor used primarily in the treatment of leukemia. Chronic Myeloid Leukemia (CML) cells contain a hybrid tyrosine kinase BCR/ABL that works to provide the cancer cell with ATP at an uncontrolled rate. Imatinib...

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Oligomycin A

Oligomycin A is a dominant analog of the Oligomycin class of macrocyclic lactones isolated from selected strains of Streptomyces sp. The class includes the analogs/isomers A through G.  Different isomers are highly specific for the disruption of...

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Oligomycin B

Oligomycin B is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity and...

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Oligomycin C

Oligomycin C is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity...

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