Chemotherapeutics

5-Azacytidine

5-Azacytidine is a ribonucleoside analog of cytidine.  It was developed by Celgene as a potential chemotherapeutic agent.  It is a potential bacteriostatic, anti-tumor and mutagenic agent.   A DNA methyltransferase inhibitor that...

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Paclitaxel (Taxol)

Paclitaxel (Taxol) is a natural product.  It is a diterpenoid compound and unique anti-tumor agent derived from the bark of the Pacific Yew tree (Taxus brevifolia).  The molecule consists of a complex diterpene with a taxane ring. It is a...

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Actinomycin D

Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation by acting as a cytotoxic inducer of apoptosis against tumor cells. This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees...

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Bleomycin A2 Sulfate, EvoPure®

Bleomycin A2 Sulfate, EvoPure® is a glycopeptide antibiotic used as a chemotherapeutic agent in cancer research studies including Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2)...

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Carboplatin

Carboplatin, a cisplatin analog, is a platinum-based antineoplastic chemotherapeutic agent that has been used in cancer research including in vitro studies on lung, neck, breast, and cervical cancers. It was co-developed by Bristol Myers Squibb and the...

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Herbimycin A

Herbimcyin is a sparingly soluble benzoquinone anti-tumor agent which interacts with the stress-induced chaperone protein Hsp90 (heat shock protein 90).Mechanism of ActionHerbimycin A binds specifically to the heat shock protein Hsp90 and to its...

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Mitoxantrone Hydrochloride

Mitoxantrone Hydrochloride is an anti-cancer agent used chemotherapeutically for leukemias and solid tumors.  It has immunosuppressive activity and inhibits proliferation of lymphocytes and induces apoptosis of antigen-presenting T-cells.  The...

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Streptozocin

Streptozocin is an anti-tumor agent commonly used in metastatic cancer of pancreatic islet cells. It is a glucosamine-nitrosourea.  Streptozocin was discovered in soil microbe Streptomyces achromogenes at Upjohn (now Pfizer).  It targets...

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Colchicine

Colchicine is a classic mitotic inhibitor, disrupting cell division by preventing assembly of microtubules in the mitotic spindle via inhibition of tubulin polymerization.  It has pleiotropic effects; It is an anti-inflammatory agent and has been...

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Doxorubicin Hydrochloride, USP

Doxorubicin HCl is an anthracycline antibiotic and 12-hydroxylated version of daunorubicin that inhibits macromolecular biosynthesis through DNA intercalation.Mechanism of ActionDoxorubicin stops the development of the topoisomerase II enzyme, which...

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10-Deacetyl Baccatin III

10-Deacetyl Baccatin III (syn: 10-DAB) is a natural organic compound produced by the Pacific Yew tree.  It is used as a key backbone intermediate for the semi-synthesis of Paclitaxel (Taxol), an anti-cancer drug and Docetaxel and their analogs. It...

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