Immunosuppressants

Epigallocatechin Gallate

Epigallocatechin Gallate, the catechin found in green tea (Camellia sinensis), has been reported to have an exhaustive list of promising bioactivity. It has antiparasitic activity against Leishmania, antiviral activity against influenza A and hepatitis B...

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Rifampicin Sodium

Rifampicin Sodium (Rifampin) is a semisynthetic antimicrobial compound with immunosuppressive properties derived from Rifamycin SV and originally developed by the Lepetit group in 1965.  Rifampicin shows activity against Gram-positive bacteria,...

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γ-Mangostin

γ-Mangostin is a xanthone naturally occuring in the mangosteen fruit. It has been widely researched for its variety of anticancer activity, including cell proliferation inhibiton, aromatase inactivation for the treatment of breast cancer,...

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Dihydrocyclosporin A

Dihydrocyclosporin A is co-metabolite of Cyclosporin A. Dihydrocyclosporin A has no immunosuppressant activity and has found use as a control to determine the role of Cyclosporin A  in pharmacology, particularly for parasitic infections...

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Myriocin

Myriocin is an α-amino fatty acid derived from several genera of fungi, notably Myriococcum, Melanconis and Isaria.Myriocin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.Mechanism of ActionMyriocin potently inhibits sphingosine...

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Zotarolimus

Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable...

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Wortmannin

Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumor and...

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L-Penicillamine

L-Penicillamine is a metabolite of penicillin that acts as a copper chelating agent. TOKU-E offers both D-penicillamine (P107) and L-penicillamine (P112). While they are enantiomers of each other with equal copper chelating ability, L-penicillamine has a...

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Ridaforolimus

Ridaforolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety. Ridaforolimus is extensively cited in the literature with over 70 citations.Ridaforolimus is...

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Clofazimine

Clofazimine is a unique lipophilic rhimophenazine dye with antibacterial, antimycobacterial, anti-inflammatory, immunsupressive, and antituberculosis properties.  It was first synthesized in 1954 by a team at Trinity College, Dublin, and was...

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Methotrexate

Methotrexate is a selective agent for dihydrofolate reductase (DHFR)- transfected cells, and a nucleic acid synthesis inhibitor in protein expression systems, thus can be used as an ancillary material in upstream biomanufacturing applications.  It...

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Caffeic acid phenethyl ester (CAPE)

Caffeic acid phenethyl ester is a natural phenolic compound from honeybee hives and has demonstrated anti-carcinogenic, anti-bacterial, and antiinflammatory properties.Mechanism of ActionCaffeic acid phenethyl ester inhibits bacterial growth by the...

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