Immunosuppressants

Baicalin

Baicalin is a flavone compound isolated from Scutellaria baicalensis Georgi and has demonstrated anti-viral and anti-inflammatory properties. SpectrumBaicalin has been shown to be effective against Influenza virus and has demonstrated inflammatory...

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Flurbiprofen Sodium

Flurbiprofen sodium is a non-steroidal anti-inflammatory drug (NSAID) used primarily as an antimiotic during opthalmic surgery, and is also an anti-inflammatory.TOKU-E also offers:  Flurbiprofen (F036) Mechanism of ActionLike many NSAID's...

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Dinactin

Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine...

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Nonactin

Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of...

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Everolimus

Everolimus is a macrocyclic lactone prepared from Rapamycin.  It is an analog of Tacrolimus, and binds to receptor protein FKBP12.  It is the most commonly used mTOR inhibitor.  Everolimus has been found to have anti-cancer properties, and...

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Luteoreticulin

Luteoreticulin is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers SNF4435C and SNF4435D. Metabolites within this class are potent antitumor agents with pronounced immunosuppressive activity, and more...

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Quinolactacin A1

Quinolactacin A1 is the dominant analogue of a family of quinolone metabolites produced by Penicillium citrinum. Quinolactacin A1 rapidly epimerises to equilibrate with its diastereomer quinolactacin A2 in protic solvents. The mixture has been shown to...

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Terrein

Terrein is a polar, substituted dihydrocyclopentenone first reported by Raistrick and colleagues in the 1930s and subsequently found in a number of Aspergillus and Penicillium species.Terrein is soluble in ethanol, methanol, DMF and DMSO.Mechanism of...

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Trinactin

Trinactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp.. Early literature reported that trinactin was a monovalent cation ionophore with high selectivity for ammonium and potassium. Trinactin has not previously been...

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TS 155-2

TS155-2 is a macrocyclic lactone related to hygrolidin but produced by a different Streptomyces species. With the exception of the original patent suggesting hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity, no literature...

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Umirolimus

Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to...

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Salicin

Salicin is a β-glucoside compound derived from the bark of willow (Salix), poplar, and various other plants.  It is a biosynthetic precursor to salicylaldehyde.  It is a natural antioxidant.  It has been used as an anti-flammatory...

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