Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo...
Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene...
Platensimycin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the...
Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a...
Tildipirosin is a semi-synthetic antibiotic derived from a tylosin derivative by iodination and reaction with piperidine. The introduction of a third basic moiety into the tylosin core provides a...
Phenelfamycin E is the major analogue of the phenelfamycin complex produced by several species of Strepyomyces. The phenelfamycins are potent antibiotics with good activity against Gram positive...
Parvodicin is a family of glycopeptides with potent antibiotic activity, isolated from Actinomadura parvosata. Structurally the parvodicins share a common cyclic peptide core with ristocetin. The...
Ostreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginiamycin complex. In the 1950s this complex was independently discovered so many times that the literature became...
L-156602 is a cyclic hexapeptide isolated from a strain of Streptomyces by researchers at Merck USA and reported in 1991. L-156602 belongs to the aurantimycin class and, like other members, is active...
Dermcidin is an antimicrobial peptide (AMP) expressed in human sweat glands and is part of the human body's innate immune defense. Several truncated versions of dermcidin naturally occur in sweat,...
Lydicamycin belongs to a novel structural class with highly selective antibiotic activity. Recent research has shown that Lydicamycin and the related metabolites, TPU-0037A and TPU-0037C, are highly...
Ionomycin was isolated from Streptomyces conglobatus as a potent Gram positive antibiotic. During isolation, it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium...
