Antimicrobials

Ionomycin

Ionomycin was isolated from Streptomyces conglobatus as a potent Gram positive antibiotic. During isolation, it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions, suggesting the metabolite acts as a calcium...

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Indanomycin

Indanomycin is an unusual pyrollic ionophore active against Gram positive bacteria and insects. Interestingly, indanomycin has antihypertensive properties. Indanomycin possesses affinity for both mono- and divalent ions, and has been reported as a growth...

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Nodusmicin

Nodusmicin is a co-metabolite of nargenicin, bearing the core macrocyclic lactone but lacking the pyrrole ester. Like nargenicin, nodusmicin is a potent antibiotic active against both aerobic and anaerobic bacteria. Lack of availability has restricted a...

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Nargenicin

Nargenicin (CP-47,444) is a 10-membered macrocyclic lactone isolated from Nocardia in 1980 as an antibiotic. The macrocyclic lactone is anchored through vicinal carbons to a decalin bearing a pyrrole ester. Nargenicin exhibits potent activity against...

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Micrococcin P1

Micrococcin P1 is a macrocyclic thiopeptide originally isolated from Micrococcus sp. by Su (Oxford) in 1948 and is considered the founding member of the thiopeptide antibiotic family.  It was purified by Heatley and Doery but the producing strain...

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Alpha-lipomycin

α-Lipomycin is an unusual pentaenone tetramic acid first isolated from Streptomyces aureofaciens in 1972. Lipomycin has potent Gram positive antibacterial activity with no activity against fungi, including yeasts. The antibiotic activity is antagonized...

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Alamethicin F50

Alamethicin F50 is a neutral linear peptaibol complex with potent antibiotic activity, containing 20 "amino acids" with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F50 is co-produced with an acidic linear peptaibol complex...

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Fidaxomicin

Fidaxomicin is the major analog of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3,...

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Dihydrotanshinone I

Dihydrotanshinone I is one of many bioactive products isolated from Salvia miltiorrhiza, a well-known traditional Chinese medicinal plant. It's primary promise lies in its anticancer activity, but it has been found to be active against gram-positive...

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Berninamycin A

Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic 'peptide' comprising atypical amino acids linked to thiazole and oxazoles. Berninamycin A is closely related to siomycin, a recently...

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Berninamycin D

Berninamycin D is an antibiotic isolated in 1994 from a strain of Streptomyces as a minor analogue of berninamycin A. Berninamycin D is a macrocyclic 'peptide' comprising atypical amino acids linked to thiazole and oxazoles but does not contain the...

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Corynecin III

Corynecin III (methamphenicol) is a member of a naturally-occurring complex of chloramphenicol-like acyl nitrophenylpropylamines isolated from Corynebacterium hydrocarboclastus in 1972. Corynecin III is active against Gram positive and Gram negative...

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