Geninthiocin is a thiopeptide antibiotic isolated from a Streptomyces sp. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl...
Aureothin, an unusual pyranone metabolite, has broad biological actions including antitumor, antimicrobial and insecticidal activities. More recently, aureothin has been shown to be a potent...
1,6-Dimethoxyphenazine is a simple phenazine produced by several species of Streptomyces. Dimethoxyphenazine is a weakly active antibacterial metabolite with activity against mycobacteria...
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases...
Cinnamycin (syn: lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium cinnamoneus, first isolated in 1952. Cinnamycin belongs to the class...
Desertomycin A is a 42-membered macrocyclic lactone with broad spectrum activity against Gram positive and Gram negative bacteria, yeasts and fungi. There has been little investigation into the mode...
Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower...
Emodin is a tyrosine kinase inhibitor and is a natural anthraquinone derivative found in the roots and rhizomes of multiple plants. It has anti-inflammatory, antiviral, antibacterial and anticancer...
Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl...
10'-Desmethoxystreptonigrin is a close analogue of streptonigrin produced by selected Streptomyces species. It is a moderately potent inhibitor of farnesylation of RAS P21 protein, 3-fold more active...
Capreomycin is a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The complex has two major components, IA and IB, with an exocyclic lysine residue and...
Mithramycin A was the first of the aureolic acid class of antitumor antibiotics, isolated from Streptomyces.Mithramycin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility...
