Antimicrobials

Kazusamycin B

Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and...

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Doxycycline Hydrate

Doxycycline Hydrate is a third-generation tetracycline and matrix metalloproteinase inhibitor, synthesized in 1958.  It has broad-spectrum antibacterial and antiprotozoan activity, and interferes with bacterial protein synthesis.  It is soluble...

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Nogalamycin

Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides: the neutral monosaccharide attaches to the D ring, similar to the aminoglycoside...

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Ikarugamycin

Ikarugamycin is a natural product with an unusual structure, a pentacyclic tetramic acid produced by Streptomyces phaeochromogenes.  Discovered in 1972, the compound belongs to the polycyclic tetramate macrolactams (PTMs) class.  It has potent...

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Enopeptin A

Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram-positive and Gram-negative bacteria, including MRSA. Enopeptin...

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Leucomycin A1

Leucomycin A1 is a major metabolite from the leucomycin complex, a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. Leucomycin A1 is one of the more potent members of the complex...

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Leucomycin A13

Leucomycin A13 is the most non-polar member of the leucomycin complex, a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis. Leucomycin A13 is used for HPLC resolution of the leucomycin complex, however no...

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Leucomycin A4

Leucomycin A4 is a major metabolite from the leucomycin complex, a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. Leucomycin A4 is one of the more potent antibiotics of the complex...

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Leucomycin A5

Leucomycin A5 is a major metabolite of the leucomycin complex, a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, and discovered in 1953. Leucomycin A5 is one of the more potent antibiotics of the complex...

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Steffimycin B

Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp. with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step,...

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Leucomycin

Leucomycin complex (kitasamycin) is a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. The complex contained over 14 components with analogues A1, A4, A5, and A13 being the most...

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Oxychloroaphine

Oxychloroaphine (1-phenazinecarboxamide) is a simple phenazine produced by many species of Pseudomonas. It is a antifungal involved in plant biocontrol with activity against Pseudomonas.  Oxychloroaphine and related phenazines are used as standards...

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