Antimicrobials

spiro-Oxanthromicin A

spiro-Oxanthromicin was first isolated from a soil-derived Streptomyces sp. by Capon in 2014. spiro-Oxanthromicin inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells (IC50 27...

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Securinine

Securinine is a tetracyclic alkaloid isolated from the roots of Securinega suffruticosa with an unusual structure in which the piperidine ring has a skewed boat form and the diene is not coplanar. Securinine inhibits [3H]GABA binding to rat brain...

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Sartorypyrone D

Sartorypyrone D is a meroterpenoid produced by Neosartorya fischeri FO-5897 and isolated by Omura and co-workers at the Kitasato Institute, Japan, in 2015. Sartorypyrone D is a potent inhibitor of NADH-fumarate reductase and NADH oxidase with IC50 OF 1.7...

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Rubiginone D2

Rubiginone D2 was isolated from a Streptomyces sp. by Zeeck and co-workers, University of Gottingen, Germany in 2000. Rubiginone D2 is an angucycline, an angular tetracyclic benzanthracene core containing a highly oxygenated A ring. Rubiginone D2 is a...

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Pyrenophorin

Pyrenophorin, the diketone analogue of pyrenophorol, was first reported as a metabolite of the oat pathogen Pyrenophora avenae showing cytostatic properties. Pyrenophorin is a simple macrocyclic dilactone with phytotoxic and antifungal activity...

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Psychotridine

Psychotridine is the main component of an alkaloid complex isolated from Psychotria beccaroides by Lamberton and colleagues (CSIRO, Australia) in 1974. Psychotridine is structurally related to hodgkinsine. The structure of psychotridine was revised in...

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Protoporphyrin Disodium

Protoporphyrin Disodium is the disodium salt of Protoporphyrin (syn: Protoporphyrin IX, PPIX), a heterocyclic organic compound and the final intermediate in heme biosynthesis.  Present in all living cells, it serves as a substrate for ferrochelatase...

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Plumbagin

Plumbagin is a yellow-orange pigment isolated from Plumbagin and other plant species. Research into Plumbagin dates back to the early 1800s, with its synthesis reported in 1936. Plumbagin has a broad biological activity, including bactericidal,...

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Piliformic Acid

Piliformic Acid is produced by fungi including Xylaria sp. Piliformic acid has mild inhibitory activity against Propionobacterium acnes, inhibiting the P. acnes-induced pro-inflammatory cytokines production in THP-1 cells. Piliformic acid is active...

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Pikromycin

Pikromycin was the first macrolide antibiotic, isolated in 1951 by the German researchers Brockmann and co-workers from Streptomyces sp. Its structure as a 14-membered lactone linked to D-desosamine was confirmed in 1957. Pikromycin is synthesized...

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Phomopsinamine

Phomopsinamine is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis. Phomopsinamine is formed by hydrolysis of the dicarboxylic acid of phomopsin A. The phomopsins cause lupinosis in livestock fed infected lupins. Phomopsinamine is a...

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Pepstatin A

Pepstatin A, a pentapeptide isolated from Streptomyces sp. is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. Pepstatin is active against HIV-1 and Plasmodium falciparum. HIV-infected H9 cells...

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