Antibacterials

Heronapyrrole B

Heronapyrrole B is a member of a family of farnesylated 2-nitropyrroles isolated from a marine-derived Streptomyces found on the Australian Barrier Reef by Capon et al at the University of Queensland, Australia. Heronapyrrole B is potently active against...

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Helvolic Acid

Helvolic Acid is a triterpenoid antibacterial mycotoxin produced by Aspergillus and other fungal species, structurally related to cephalosporin P1 and fusidic acid. Helvolic acid is active against Gram positive and Gram negative organisms, including...

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Griseofulvic Acid

Griseofulvic acid is a naturally occurring polyketide metabolite of the griseofulvin family. Griseofulvic acid, the demethylated metabolite of griseofulvin, is excreted in the urine of humans administered griseofulvin for the treatment of fungal...

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Fumitremorgin B

Fumitremorgin B is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Fumitremorgin B is active against a range of phytopathogenic fungi including Botrytis cinerea, Alternaria solani and alternata at 6.25 µg/mL. Fumitremorgen B has potent...

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Stephacidin B

Stephacidin B, the dimer of avrainillamide, is green pigment isolated from Aspergillus ochraceus and other Aspergillus sp.  Stephacidin B is more potent and selective than its monomeric analog, stephacidin A. Stephacidin B is rapidly converted to...

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Fervenulin

Fervenulin, structurally related to caffeine, was first isolated from Streptomyces fervens in 1959 and reported as a broad spectrum antibiotic, with antineoplastic properties. Fervenulin inhibits egg hatch and increases juvenile mortality of the...

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Ethyl Mycophenolate

Ethyl mycophenolate is the ethyl ester of mycophenolic acid produced by Penicillium brevicompactum but devoid of the antifungal activity of mycophenolic acid. There are few reports of the biological activity of ethyl mycophenolate, however its analogue...

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Erythromycin 2'-propionate

Erythromycin 2-propionate is the propionic acid ester precursor of erythromycin, the 14-membered macrocyclic lactone produced by Streptomyces erythreus. Erythromycin propionate displays an MIC of 0.01 – 0.05 ug/mL when tested against Micrococcus...

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Epirubicin Hydrochloride

Epirubicin is the 4'-epi-isomer of the antitumor agent, doxorubicin. Epirubicin acts by inhibiting topoisomerase II resulting in DNA double strand breaks. The anthracyclines also act by evicing histone from open chromatin, deregulating the...

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Emeguisin A

Emeguisin A was first isolated from the fungus Emericella unguis by Yamakazaki and coworkers from Hoshi University, Japan in 1988. Emeguisin A exhibits potent antibacterial activity against Staphylococcus aureusincludin methicillin-​resistant strains, as...

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Echinosporin

Oligomycins and pamamycin homologs impair motility and induce lysis of zoospores of the grapevine downy mildew pathogen, Plasmopara viticola. Dame Z.T. et al. FEMS Microbiol Lett. 2016, 363, 167. Molecular Formula  C10H9NO5 References Cui...

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DL-2,6-Diaminopimelic Acid

DL-2,6-Diaminopimelic Acid is a stereoisomer of mesodiaminopimelic acid (meso-DAP), a constituent of the peptidoglycans present in the cell walls of algae and most bacteria. DL-Diaminopimelic Acid is found in the cell wall of some actinomycetes,...

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