Antiparasitics

Cytochalasin H

Cytochalasin H is one of a family of potent mycotoxins produced by a range of fungi. In vitro, cytochalasin H exhibits antibacterial, antifungal, nematocidal and antitumor activity.Cytochalasin H is soluble in ethanol, methanol, DMF and DMSO...

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Borrelidin

Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.Borrelidin is soluble in ethanol, methanol, DMF and...

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Doramectin aglycone

Doramectin aglycone is an acid degradation product produced by hydrolysis of the disaccharide unit of doramectin. Doramectin aglycone is an inhibitor of nematode larval development, but is devoid of paralytic activity. Despite the importance of...

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Epi-doramectin

Epi-Doramectin is a base-catalysed intermediate in the decomposition of doramectin. epi-Doramectin is formed by epimerisation at the 2-position which ultimately rearranges irreversibly to the isomeric alkene analogue, ?2-doramectin. Despite the...

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Delta-2-doramectin

Delta-2-Doramectin is an irreversible base degradation product of doramectin found in animals treated with doramectin and in the environment. ?2-Doramectin is formed by rearrangement of the naturally occurring ?3-group in doramectin to the 2-position...

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Drimentine A

Drimentine A belongs to a novel class of antibiotics, possessing a new terpenylated diketopiperazine structure, with antibiotic, antifungal and anthelmintic activity.  Unlike Drimentine B and Drimentine C, Drimentine A does not have anticancer...

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Drimentine B

Drimentine B belongs to a novel class of antibiotics, possessing a new terpenylated diketopiperazine structure, with antibiotic, antifungal and anthelmintic activity.Drimentine B is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility...

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Drimentine C

Drimentine C belongs to a novel class of antibiotics, possessing a new terpenylated diketopiperazine structure, with antibiotic, antifungal and anthelmintic activity.Drimentine C is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility...

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Dihydrospinosyn A aglycone

Dihydrospinosyn A aglycone is an acid degradation product produced by hydrolysis of both saccharide groups of 3'-ethoxy-5,6-dihydrospinosyn J, the major component of the commercial insecticide, Spinetoram. Dihydrospinosyn A aglycone is only weakly active...

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Concanamycin B

Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A.Concanamycin B is soluble in ethanol,...

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Derquantel

Derquantel is a semi-synthetic paraherquamide analog, derived from a fermentation product of Penicillium simplicissimum via chemical reduction.  It is an anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist. ...

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Puromycin

Puromycin is an aminonucleoside antibiotic with anti-trypanosomal and antineoplastic properties.  It was isolated from Streptomyces alboniger in the 1950s. Puromycin is used in cell biology to select for mammalian cell lines that have been...

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