Spinosyn D, >90% (6-methyl-spinosyn A) is the minor component of Spinosad and makes up to 15% of Spinosad. Spinosyn D differs from Spinosyn A by having a methyl group instead of a hydrogen atom at position C6 on the macrolide. Spinosyn D is a potent insecticide for crop protection. The spinosyns have a unique mode of action involving disruption of nicotinic acetylcholine receptors.
Spinosyn D is soluble in ethanol, methanol, DMF and DMSO.
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| Mechanism of Action | Spinosyn A resembles a GABA antagonist and is comparable to the effect of avermectin on insect neurons. |
| Spectrum | Saccharopolyspora spinosa |
| Plant Biology Applications |
Spinosad is a natural product approved for use in organic agriculture as an insecticide and crop protectant. It has an excellent environmental and mammalian toxicological profile. |
| Molecular Formula | C42H67NO10 |
| References |
Kirst HA (2010) The spinosyn family of insecticides: Realizing the potential of natural products research. J. Antibiotics 63:101-111 Kirst HA et al (191) A 83543A-D, unique fermentation-derived tetracyclic macrolides. Tetrahedron Lett. 32:4839 Lopez O and Fernandez-Bolanos JG ed. (2011) The Spinosyn insecticides. In: Green trends in insect control. RSC Green Chemistry Series No. 11, RSC Publishing, Ch. 5: pp 163-212 |
