Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp. with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.
Steffimycin B is soluble in ethanol, methanol, DMF and DMSO.
Steffimycin B is soluble in ethanol, methanol, DMF and DMSO.
| References | Molecular structure of antitumor drug steffimycin and modeling of its binding to DNA. Sriram M. et al. J. Biomol. Struct. Dyn. 1991, 9, 251. Screening of antibiotics preferentially active against ras oncogene-expressed cells. Suzukake-Tsuchiya K. et al. J. Antibiot. 1990, 43, 1489. Steffimycin B, a DNA binding agent. Reusser F. Biochim. Biophys. Acta 1975, 383, 266. |
