Sulfachloropyridazine is a broad-spectrum sulfonamide antibiotic that can be used for bacteria causing urinary tract infections. It is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA) which is required for bacterial folic acid synthesis. It is frequently used in veterinary research, and has been found to bolster the immune system in plants.
| Mechanism of Action | Sulfachloropyridazine inhibits the enzyme dihydropteroate synthase, thereby blocking dihydrofolic acid synthesis. |
| Spectrum | broad-spectrum, effective against Gram-positive and Gram-negative bacteria. Also effective for Mycoplasma. |
| Microbiology Applications | Sulfachloropyridazine can be used to study metabolic pathways, reaction kinetics, and toxicity profiles. |
| Plant Biology Applications | High-throughput screening of Arabidopsis plant suspensions were used to screen libraries of bioactive molecules and natural products for plant activators (agrochemicals that activate the plant immune system and protect crops from disease). Sulfachlorpyridazine was found to be a candidate that increased disease resistance, using Pseudomonas syringae pv. tomato. (Noutoshi et al, 2012). |
| Molecular Formula | C10H9ClN4O2S |
| References | Conde-Cid M et al (2018) Degradation of sulfadiazine, sulfachloropyridazine and sulfamethazine in aqueous Dirany A, Sirés I, Oturan N, Ozcan A, Oturan MA (2012) Electrochemical treatment of the antibiotic sulfachloropyridazine: Kinetics, Noutoshi Y, Ikeda M, Saito T, Osada H and Shirasu K (2012) Solfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana. Front. Plant Sci. 3:245 PMID 23118736 Wang Z, Zhang S, Nesterenko IS, Eremin SA and Shen J (2007) Monoclonal antibody-based fluorescence polarization immunoassay for sulfamethoxypyridazine and sulfachloropyridazine. J. Agric. Food Chem. 5(17):6871-6878 |
