SKU: U005  / 
    CAS Number: 112953-11-4

    UCN-01

    $688.06 - $2,408.26
    UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.

    UCN-01 is soluble in ethanol, methanol, DMF and DMSO. 
    Mechanism of ActionUCN-01 inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis.
    Molecular FormulaC28H26N4O4
    ReferencesUCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway. Facchinetti M.M. et al. Cancer Res. 2004, 64, 3629. 

    UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century? Akinaga S. et al. Anticancer Drug Des. 2000, 15, 43. 

    UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. Takahashi I. et al. J. Antibiot. 1989, 42, 571.