UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumor activity but is devoid of antimicrobial activity.
| Mechanism of Action | UK-1 acts as a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II. |
| Molecular Formula | C22H14N2O5 |
| References | UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physicochemical and biological properties. Ueki M. et al. J. Antibiot. 1993, 46, 1089. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II Structure elucidation. Shibata K. J. Antibiot. 1993, 46, 1095. The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II. Reynolds M. B. et al. Bioorg. Chem. 1999, 27, 326. |
