WF 3681 was isolated from Chaetomella sp. as a novel inhibitor of aldose reductase by researchers at Fujisawa Co. Japan in 1987, exhibiting an IC50 of 2.5 x 10-7 M. WF 3681 does not significantly reduce accumulation of sorbitol in rat sciatic nerves of diabetic rats. The structure of WF 3681 was confirmed in 1988.
| Molecular Formula |
C13H12O5 |
| References |
- Kissinger CR et al (1988) Structure of WF-3681, 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid. Acta crystallographica. Section C, Crystal Structure Comm. 44:512
- Nishikawa M et al (1987) Studies on WF-3681, a novel aldose reductase inhibitor. I. Taxonomy, fermentation, isolation and characterization. J Antibiot. 40:1394
- Nishiwaka M et al (1990) Studies on WF-3681, a novel aldose reductase inhibitor. III. Effect of WF-3681 and its derivatives on sorbitol accumulation in diabetic rats. J Antibiot. 43:1186
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