SKU: W003  / 
    CAS Number: 105364-56-5

    WF 3681

    ₱13,049.16 - ₱45,495.72

    WF 3681 was isolated from Chaetomella sp. as a novel inhibitor of aldose reductase by researchers at Fujisawa Co. Japan in 1987, exhibiting an IC50 of 2.5 x 10-7 M. WF 3681 does not significantly reduce accumulation of sorbitol in rat sciatic nerves of diabetic rats. The structure of WF 3681 was confirmed in 1988.

    Molecular Formula  C13H12O5
    References
    • Kissinger CR et al (1988)  Structure of WF-​3681, 3-​(2,​5-​dihydro-​4-​hydroxy-​5-​oxo-​3-​phenyl-​2-​furyl)​propionic acid. Acta crystallographica. Section C, Crystal Structure Comm. 44:512 
    • Nishikawa M et al (1987)  Studies on WF-3681, a novel aldose reductase inhibitor. I. Taxonomy, fermentation, isolation and characterization. J Antibiot. 40:1394
    • Nishiwaka M et al (1990)  Studies on WF-3681, a novel aldose reductase inhibitor. III. Effect of WF-3681 and its derivatives on sorbitol accumulation in diabetic rats. J Antibiot. 43:1186