SKU: Z014  / 
    CAS Number: 1436861-97-0

    Zidebactam

    ৳50,504.85 - ৳160,697.25

    Zidebactam is a non-β-lactam antibiotic that is categorized as a diabicyclooctane (DBO). It is a penicillin-binding protein 2 (PBP2) inhibitor with a high affinity for PBP2 in Gram-negative bacteria. When used in combination with cefepime, it can enhance the activity of cefepime against multi-drug resistant Pseudomonas aeruginosa. These BLBLI combinations (β-Lactam-β-lactamase inhibitor) are used to retain the activity of β-lactam antibiotics and extend the activity against bacteria that can produce the β-lactamase enzyme.

    Zidebactam is soluble in DMSO.

    Mechanism of Action Zidebactam has a dual mechanism of action: Binding to penicillin binding protein2 (PBP2), and β-lactamase inhibition.
    Spectrum Zidebactam is active against Gram-negative bacteria. It can be used for multi-drug resistant strains of Acinetobacter baumannii.
    Microbiology Applications

    Zidebactam can be used together with cefepime to combat Enterobacteriaceae. A. baumannii is intrinsically resistant to many antibiotics due to its low outer membrane permeability.

    Molecular Formula C13H21N5O7S
    References

    Moya B et al (2017) Potent β-lactam enhancer activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, including carbapenemase-producing clinical isolates. Antimicrob. Agents Chemother. 61(11):e01238-17 PMID 28848013

    Sader HS et al (2017) WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob. Chemother. 72(6):1696-1703 PMID 28333332