Zidebactam is a non-β-lactam antibiotic that is categorized as a diabicyclooctane (DBO). It is a penicillin-binding protein 2 (PBP2) inhibitor with a high affinity for PBP2 in Gram-negative bacteria. When used in combination with cefepime, it can enhance the activity of cefepime against multi-drug resistant Pseudomonas aeruginosa. These BLBLI combinations (β-Lactam-β-lactamase inhibitor) are used to retain the activity of β-lactam antibiotics and extend the activity against bacteria that can produce the β-lactamase enzyme.
Zidebactam is soluble in DMSO.
| Mechanism of Action | Zidebactam has a dual mechanism of action: Binding to penicillin binding protein2 (PBP2), and β-lactamase inhibition. |
| Spectrum | Zidebactam is active against Gram-negative bacteria. It can be used for multi-drug resistant strains of Acinetobacter baumannii. |
| Microbiology Applications |
Zidebactam can be used together with cefepime to combat Enterobacteriaceae. A. baumannii is intrinsically resistant to many antibiotics due to its low outer membrane permeability. |
| Molecular Formula | C13H21N5O7S |
| References |
Moya B et al (2017) Potent β-lactam enhancer activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, including carbapenemase-producing clinical isolates. Antimicrob. Agents Chemother. 61(11):e01238-17 PMID 28848013 Sader HS et al (2017) WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob. Chemother. 72(6):1696-1703 PMID 28333332 |