4-Epitetracycline HCl, EvoPure® is a highly purified hydrochloride salt form of 4-Epitetracycline. Under acidic conditions, Tetracycline undergoes an epimerization at the fourth carbon, producing a mixture of Tetracycline and 4-Epitetracycline. This EvoPure product is soluble in water.
For other Tetracycline products, click here.
| Application | 4-Epitetracycline HCl, EvoPure® can be used as an analytical standard. |
| Mechanism of Action | Tetracycline inhibits the growth of Gram-positive and Gram-negative bacteria by disrupting codon-anticodon interactions at the ribosome, thus blocking protein synthesis. Specifically, Tetracycline binds to the 30S ribosomal subunit and blocks the attachment of charged aminoacyl-tRNA to the A site on the ribosome, preventing peptide elongation. |
| Spectrum | Effective against Gram-positive and Gram-negative bacteria, and Mycoplasma. |
| Molecular Formula | C22H24N2O8 · xHCl (lot specific) |
| Molecular Weight | 444.43 g/mol (Free base. Actual molecular weight shown on lot specific certificate of analysis). |
| References | Mazur X, Eppenberger HM, Bailey JE and FUssenegger M (2000) A novel autoregulated proliferation-controlled production process using recombinant CHO cells. Biotechnol and Bioeng. 65(2):144-150 Fernandez AA, Noceda VT, Carrera ES (1969) Simultaneous separation and quantitative determination of tetracycline, anhydrotetracycline, 4-epitetracycline, and 4-epi-anhydrotetracycline in degraded tetracyclines by thin-layer chromatography. J. Pharm. Sci. 58(4):443-446 |
