SKU: A059  / 
    CAS Number: 34642-77-8

    Amoxicillin Sodium

    ₱3,944.81 - ₱18,060.76

    Amoxicillin Sodium is an extended spectrum β-lactam antibiotic and is similar in structure to Ampicillin. Resistance to Amoxicillin can be attributed to β-lactamase enzymes secreted by a resistant cell.  Amoxicillin Sodium is soluble in aqueous solution.

    We also offer:

    • Amoxicillin Trihydrate (A004)
    • Amoxicillin:Potassium Clavulanate (2:1) (A054)
    Mechanism of Action Like all β-lactams, Amoxicillin targets PBP’s (penicillin binding proteins) involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to the death of the cell.
    Spectrum Amoxicillin targets a wide range of β-lactamase negative Gram-positive and Gram-negative bacteria including E. coli and a number of Streptococcus and Staphylococcus species. Because peptidoglycan is synthesized in Gram-positive and Gram-negative bacteria, Amoxicillin can be used against a wide variety of species.
    Microbiology Applications Amoxicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    • Neisseria gonorrhoeae 0.3 µg/mL - 32 µg/mL
    • Haemophilus influenzae 0.125 µg/mL - >64 µg/mL
    • For a representative list of Amoxicillin MIC values, click here.
    Eukaryotic Cell Culture Applications Dendritic cells were incubated with supernatant from Amoxicillin-treated hepatocytes in vitro to characterize signaling pathways between hepatocytes and immune cells to study the compound's influence on the immune response (Ogese, 2017).
    Molecular Formula C16H18N3NaO5S
    Impurities Related Substances
    Amoxicillin dimer: ≤3.0%
    Any impurity: ≤3.0%
    Sum of impurities: ≤9.0%
    2-Ethyl hexanoic acid: ≤1.0%
    Residual Solvents Ethanol: ≤0.5%
    Methyl acetate: ≤0.5%
    References

    Ogese MO (2017) Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 158(1):76-89 PMID 28444390

    Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 103(1):51-59. PMID 9236486

    Worlitzch D et al (2001) Effects of Amoxicillin, gentamicin, and moxifloxacin on the hemolytic activity of Staphylococcus aureus in vitro and in vivo. Antimicrob Agents Chemother. 45(1):196-202 PMID 11120965</em<>

    MIC Aggregatibacter actinomycetemcomitans| 1 - 16|| Bacillus cereus| 4 - 31.25|| Bacillus pumilu| 1|| Bacillus subtilis| 0.05 - 412|| Bacteroides distasonis| 2 - >128|| Bacteroides fragilis| ≤0.25 - ≥512|| Bacteroides ovatus| 16 - >128|| Bacteroides thetaiotaomicron| 16 - >128|| Bacteroides uniformis| 16 - >128|| Bacteroides vulgatus| 8 - >128|| Bifidobacterium spp.| ≤0.125 - 0.5|| Borrelia burgdorferi S.L.| 0.03 - 2|| Burkholderia cepacia (8Q)| >18|| Burkholderia mallei (Pakistan)| 128|| Campylobacter gracilis (ATCC 33236)| 1|| Campylobacter helveticus (ATCC 51209)| 4|| Campylobacter jejuni| 0.5 - 2|| Campylobacter rectus (ATCC 33238)| 1|| Campylobacter showae (ATCC 51146)| 0.5|| Capnocytophaga gingivalis (ATCC 33624)| 0.5|| Capnocytophaga ochracea (ATCC 27872)| 1|| Capnocytophaga spp.| 1|| Capnocytophaga sputigena (ATCC 33612)| 1|| Citrobacter diversus| >1000|| Citrobacter freundii| 2 - 2048|| Clostridium bifermentans| ≤0.125 - 0.5|| Clostridium cadaveris| ≤0.125 - 0.5|| Clostridium difficile| 1 - 4|| Clostridium histolyticum | ≤0.125 - 0.5|| Clostridium perfringens| ≤0.03 - 0.5|| Clostridium ramosum| ≤0.125 - 0.5|| Clostridium sordellii| ≤0.125 - 0.5|| Clostridium spiroforme| 0.032 - 0.5|| Clostridium spp.| ≤0.125 - 0.5|| Clostridium tertium| ≤0.125 - 0.5|| Corynebacterium matruchotii (ATCC 14266)| 0.5|| Corynebacterium spp. (HEGP 1006)| >256|| Edwardsiella hoshinae | 0.13 - 0.25|| Edwardsiella ictaluri | 0.13 - 1|| Edwardsiella tarda| 0.13 - 64|| Eikenella corrodens| 2 - 8|| Enterobacter cloacae| 4 - >500|| Enterobacteriaceae| 0.25 - 128|| Enterococci| 0.12 - 128|| Enterococcus faecalis| 0.25 - 7|| Enterococcus faecium| 32 - >256|| Escherichia coli| 2 - >500|| Eubacterium saburreum (ATCC 33271)| 0.5|| Eubacterium spp.| 1|| Eubacterium sulci (ATCC 35585)| 0.5|| Fusobacterium mortiferum| 1 - >128|| Fusobacterium necrophorum| ≤0.125 - 0.5|| Fusobacterium nucleatum| ≤0.125 - 16|| Fusobacterium periodonticum (ATCC 33693)| 32|| Fusobacterium spp.| ≤0.125 - >128|| Fusobacterium varium| 1 - 2|| Gemella morbillorum (ATCC 27824)| 0.5 - ?|| Haemolytic streptococci| 0.008 - 0.12|| Haemophilus ducreyi| 9|| Haemophilus influenzae| <0.07 - >64|| Haemophilus parasuis| 0.6 - 310|| Haemophilus spp.| 0.06 - 128|| Helicobacter bilis (ATCC 51630)| 4|| Helicobacter mustelae (ATCC 43772)| 4|| Helicobacter pullorum (ATCC 51864)| 4|| Helicobacter pylori| 0.0002 -8|| Klebsiella pneumonia| 2 - >500|| Lactobacillus acidophilus| ≤0.125 - 2|| Lactobacillus buchneri | 0.25 - 1|| Lactobacillus plantarum| ≤0.125 - 2|| Lactobacillus reuteri| ≤0.125 - 4|| Lactobacillus rhamnosus| 0.5 - 2|| Lactobacillus salivarius | ≤0.125 - 0.5|| Lactobacillus spp.| 0.5 - 129|| Lactococcus lactis| ≤0.125 - 1|| Leptotrichia buccalis (ATCC 14201)| 0.5|| Leuconostoc | ≤0.125 - 1|| Micrococcus| <0.24 - >40|| Moraxella catarrhalis (BC1)| <0.07|| Morganella morganii| >100 - 512|| Mycoplasma hyopneumoniae| 0.09 - 737.3|| Mycoplasma hyorhinis| 0.09 - 737.3|| Neisseria gonorrhoeae| 0.3|| Neisseria meningitidis (N2)| <0.07|| Neisseria mucosa (ATCC 19696)| 2|| Neisseria spp.| 0.004 - 32|| Nocardia asteroides| 6.2 - ≥400|| Ochrobactrum anthropi (SLO74)| ≥28|| Pasteurella multocida| 128 - 1240|| Pediococcus | ≤0.125 - 1|| Peptostreptococcus anaerobius| ≤0.125 - 32|| Peptostreptococcus asaccharolyticus| ≤0.125 - 32|| Peptostreptococcus magnus| ≤0.125 - 32|| Peptostreptococcus micros| ≤0.125 - 32|| Peptostreptococcus prevotii| ≤0.125 - 32|| Peptostreptococcus spp.| <1 - 8|| Peptostreptococcus tetradius| ≤0.125 - 32|| Pneumococci| 0.008 - 4|| Porphyromonas asaccharolytica| ≤0.0125 - 64|| Porphyromonas endodontalis (ATCC 35406)| 4|| Porphyromonas gingivalis| ≤0.0125 - 64|| Porphyromonas spp.| ≤0.125 - 128|| Prevotella bivia| ≤0.125 - 128|| Prevotella buccae| ≤0.0125 - 64|| Prevotella corporis | ≤0.0125 - 64|| Prevotella disiens| ≤0.0125 - 64|| Prevotella intermedia| ≤0.0125 - 64|| Prevotella loescheii| ≤0.0125 - 64|| Prevotella melaninogenica| ≤0.125 - 128|| Prevotella nigrescens| 0.5|| Prevotella oralis (group)| ≤0.0125 - 64|| Prevotella oris| ≤0.0125 - 64|| Prevotella spp.| ≤0.125 - 128|| Propionibacterium acnes| ≤0.125 - 0.25|| Proteus mirabilis (1287)| 0.39|| Proteus vulgaris| 1 - 1024|| Providencia rettgeri (NIH 96)| 3.13|| Pseudomonas aeruginosa| 1 - 1024|| Ralstonia pickettii| 64|| Salmonella spp.| 1|| Salmonella typhi| 6.25 - 32|| Selenomonas noxia| 0.5|| Serratia marcescens| 16 - >256 - ?|| Shigella flexneri| 2|| Staphylococci| 0.03 - 128|| Staphylococcus aureus| <0.0625 - >128|| Staphylococcus aureus (methicillin-resistant)| 0.2 - 512|| Staphylococcus epidermidis| 0.78 - 1|| Staphylococcus faecalis| 1.22 - 1.95|| Streptococcus agalactiae | 0.094|| Streptococcus anginosus| 0.5|| Streptococcus bovis| ≤0.125 - 1|| Streptococcus constellatus (ATCC 27823)| 0.5|| Streptococcus equi | 0.03 - 0.06|| Streptococcus faecalis (ATCC 29212)| 412|| Streptococcus gordonii (ATCC 10558)| 0.5|| Streptococcus infantarius | ≤0.125 - 1|| Streptococcus intermedius (ATCC 27335)| 1|| Streptococcus mitis (ATCC 49456)| 0.5|| Streptococcus oralis (ATCC 35037)| 0.5|| Streptococcus pneumonia| ≤0.008 - 31.25|| Streptococcus pyogenes| 32|| Streptococcus sanguinis| 1|| Streptococcus spp.| 32 - 128|| Streptococcus suis| 78 - 1240|| Tannerella forsythia| 8|| Veillonella parvula| 0.5|| Weissella spp.| ≤0.125 - 0.25|| Xanthomonas oryzae| 18||