Berkleylactone E is a major analog of a family of recently described macrolide antibiotics, isolated from a mixed fermentation of two Penicillium species. Berkleylactone E is active against Gram-positive bacteria, Candida albicans and Candida glabrata, with an undescribed but purportedly novel mode of action. Berkeleylactone E is an analog of A 26771B.
Stierle AA et al (2017) The berkeleylactones, antibiotic macrolides from fungal coculture. J. Nat. Prod. 80:1150