Capreomycin Sulfate is the sulfate salt of Capreomycin, a broad-spectrum, cyclic peptide antiphlogistic antibiotic often grouped with the aminoglycosides. The product is a mixture of 1A and 1B forms. It can be used to study bacterial ribosomes and protein synthesis. It is bacteriostatic but can also be used to study multidrug-resistant tuberculosis. It was discovered from Streptomyces capreolus in 1960, with FDA filing by Eli Lilly in the US in 1971.
Capremycin Sulfate is freely soluble in water.
|Mechanism of Action||The mode of action of capreomycin is not well defined but it is thought to inhibit protein synthesis by inhibiting normal ribosomal functions.|
|Spectrum||Capreomycin is used for Gram-positive, Gram-negative bacteria, and Mycobacteria including M. tuberculosis.|
|Molecular Formula||1A: C25H44N14O8 •H2SO4 |
1B: C25H44N14O7 •H2SO4
Akbergenov R et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob. Agents Chemother. 55(10):4712-4717 PMID 21768509
Liu XM and Xiu JP (2012) Action and resistance mechanisms of Capreomycin: A functional genomic perspective. Inst. Modern Biopharm. 43(8):788-792