Capreomycin Sulfate, USP is the sulfate salt of Capreomycin, a broad-spectrum, cyclic peptide antiphlogistic (anti-inflammatory) antibiotic often grouped with the aminoglycosides. The product is a mixture of 1A and 1B forms. It can be used to study bacterial ribosomes and protein synthesis. It is bacteriostatic but can also be used to study multidrug-resistant tuberculosis (MDR-TB). It was discovered from Streptomyces capreolus in 1960, with FDA filing by Eli Lilly in 1971 (US).
Capremycin Sulfate is freely soluble in water.
We also offer:
- Capreomycin (C162)
| Mechanism of Action | The mode of action of Capreomycin is not well defined but it is thought to inhibit protein synthesis by inhibiting normal ribosomal functions. |
| Spectrum | Capreomycin is used for Gram-positive, Gram-negative bacteria, and Mycobacteria including M. tuberculosis. |
| Microbiology | The basis of resistance to Capreomycin was studied by isolating and characterizing Capreomycin-resistant strains of Mycobacterium smegmatis and M. tuberculosis. Mutations were found in the tlyA genes of 28 spontaneous Capreomycin-resistant mutants generated from three different M. tuberculosis strains and in the tlyA genes of Capreomycin-resistant clinical isolates also. During in vitro transcription-translation assays, ribosomes from tlyA mutant but not tlyA(+) strains resist Capreomycin inhibition of transcription-translation. Therefore, tlyA appears to affect the ribosome, and mutation of tlyA confers Capreomycin resistance (Maus et al, 2005). |
| Molecular Formula | 1A: C25H44N14O8 •H2SO4 1B: C25H44N14O7 •H2SO4 |
| References |
Akbergenov R et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob. Agents Chemother. 55(10):4712-4717 PMID 21768509 Liu XM and Xiu JP (2012) Action and resistance mechanisms of Capreomycin: A functional genomic perspective. Inst. Modern Biopharm. 43(8):788-792 Maus CE, Plikaytis BB, Shinnick TM (2005) Mutation of tlyA confers Capreomycin resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 49(2):571-577 PMID 15673735 Reisfeld B et al (2012) A physiologically based pharmacokinetic model for Capreomycin. Antimicrob Agents Chemother. 56(2):926-934 PMID 22143528 |