SKU: C009  / 
    CAS Number: 123171-59-5

    Cefepime Hydrochloride, USP

    S/.1,557.63
    Cefepime Hydrochloride, USP
    • Detailed Description

      CAS Number: 123171-59-5

      Molecular Formula: C19H25ClN6O5S2 · HCl · H2O

      Molecular Weight: 571.50

      Mechanism of Action: Like β-lactams, cephalosporins interfere with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Interestingly, Cefepime is resistant to various β-lactamases encoded by otherwise resistant β-lactam bacteria strains.

      Storage Conditions: -20°C. Protect from light.

      Tariff Code: 2941.90.5000

    • Applications

      Spectrum: Cefepime is a broad-spectrum antibiotic targeting a wide variety of naturally antibiotic resistant Gram-positive and Gram-negative bacteria. Some of these naturally resistant bacteria include Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.

      Microbiology Applications: Cefepime Hydrochloride is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:

      • Pseudomonas aeruginosa 32 µg/mL – 256 µg/mL
      • Staphylococcus aureus 2 µg/mL – 16 µg/mL
      • For a representative list of Cefepime MIC values, click here.

      Cefepime was used in a MALDI-TOF MS-based direct-on-target mirodroplet growth assay as part of a screening panel for rapid detection of ESBL, and AmpC β-Lactamases in Enterobacterales.  (Correa-Martinez et al, 2019). 

    • Specifications

      Form: Powder

      Appearance: White or almost white crystalline powder

      Source: Semi-synthetic

      Water Content (Karl Fischer): 3.0-6.0%

      Assay: (On Dried Basis): 825 – 911 μg/mg

      Absorbance: A400≤0.2

      Identification: E isomer: ≤0.2%
      Any individual impurity: ≤0.2%

    • Technical Data

      Solubility: Soluble in aqueous solution (40 mg/ml)

    Cefepime Hydrochloride, USP is the hydrochloride salt of Cefepime. The addition of the hydrochloride salt enhances aqueous solubility. It is similar in potency to Cefepime, a broad-spectrum, fourth-generation cephalosporin antibiotic that was patented in 1982 by Bristol-Myers Squibb. Cefepime is bactericidal against a wide range of Gram-positive and Gram-negative bacteria, disrupting bacterial cell wall synthesis. It appears to be intrinsically more resistant to hydrolysis by β-lactamases and is commonly used in antimicrobial susceptibility testing. Cefepime Hydrochloride is soluble in water.

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    CAS Number: 123171-59-5

    Molecular Formula: C19H25ClN6O5S2 · HCl · H2O

    Molecular Weight: 571.50

    Mechanism of Action: Like β-lactams, cephalosporins interfere with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Interestingly, Cefepime is resistant to various β-lactamases encoded by otherwise resistant β-lactam bacteria strains.

    Storage Conditions: -20°C. Protect from light.

    Tariff Code: 2941.90.5000

    Spectrum: Cefepime is a broad-spectrum antibiotic targeting a wide variety of naturally antibiotic resistant Gram-positive and Gram-negative bacteria. Some of these naturally resistant bacteria include Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.

    Microbiology Applications: Cefepime Hydrochloride is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:

    • Pseudomonas aeruginosa 32 µg/mL – 256 µg/mL
    • Staphylococcus aureus 2 µg/mL – 16 µg/mL
    • For a representative list of Cefepime MIC values, click here.

    Cefepime was used in a MALDI-TOF MS-based direct-on-target mirodroplet growth assay as part of a screening panel for rapid detection of ESBL, and AmpC β-Lactamases in Enterobacterales.  (Correa-Martinez et al, 2019). 

    Form: Powder

    Appearance: White or almost white crystalline powder

    Source: Semi-synthetic

    Water Content (Karl Fischer): 3.0-6.0%

    Assay: (On Dried Basis): 825 – 911 μg/mg

    Absorbance: A400≤0.2

    Identification: E isomer: ≤0.2%
    Any individual impurity: ≤0.2%

    Solubility: Soluble in aqueous solution (40 mg/ml)