Cefozopran Hydrochoride is a broad-spectrum, fourth-generation cephalosporin that interferes with bacterial peptidoglycan synthesis. The product is freely soluble in DMSO and slightly soluble in water.
| Mechanism of Action | Similar to β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. |
| Spectrum | Cefozopran is a broad-spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa. |
| Microbiology Applications | Cefozopran has been shown to be useful against the multi drug resistant MRSA when used in combination with other antibiotics including vancomycin and teicoplanin. |
| Molecular Formula | C19H17N9O5S2•HCl |
| Solubility | Freely soluble in DMSO. Slightly soluble in water. |
| References | Georgopapadakou NH and Bertasso A (1992) Mechanisms of action of Cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents Chemother. 37(3):559-565 PMID 8384817 Iizawa Y et al (1993) Therapeutic effect of Cefozopran (SCE-2787), a new parenteral cephalosporin, against experimental infections in mice. Antimicrob. Agents Chemother. 37(1):100-105 PMID 8431004 Toyokawa M et al (2003) In vitro combined effects of Cefozopran/teicoplanin and Cefozopran/vancomycin on methicillin-resistant Staphylococcus aureus. J. Chemother. 15(1):31-36 PMID 12678411 |
| MIC | Agrobacterium radiobacter| 1 － 16|| Alcaligenes faecalis| 0.5 － >64|| Bordetella bronchiseptica| 0.25 － >64|| Brevundimonas vesicularis| 1 － >64|| Burkholderia cepacia| 16 － >64|| Chryseobacterium indologenes| 0.5 － >64|| Chryseobacterium meningosepticum| 116 － >64|| Comamonas acidovorans| 4 － >64|| Ochrobactrum anthropi| 4 － >64|| Oligella ureolytica| 1 － >64|| Pseudomonas aeruginosa| 0.5 － 16|| Pseudomonas oryzihabitans| ≤0.06 － >64|| Pseudomonas stutzeri| ≤0.06 － >64|| Ralstonia pickettii | 0.25 － 4|| Sphingomonas spp.| 0.5 － 16|| Stenotrophomonas maltophilia| 32 － 256|| Weeksella virosa | 0.25 － 32|| |
