SKU: C016  / 
    CAS Number: 80210-62-4

    Cefpodoxime, Free Acid

    7,432,597.84₫

    Cefpodoxime free acid is a third-generation cephalosporin β-lactam antibiotic.

    TOKU-E offers three forms of cefpodoxime: Cefpodoxime Proxetil (C015), Cefpodoxime Sodium (C096), and Cefpodoxime Free Acid (C016). All forms are soluble in DMSO (dimethyl sulfoxide).

    Alm et al. used cefpodoxime from TOKU-E against Escherichia coli NDM isolates in microdilution MIC assays. "Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3.

    Mechanism of ActionLike β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.
    SpectrumCefpodoxime free acid is a broad spectrum antibiotic which targets a wide variety of gram positive and gram negative bacteria especially those which cause otitis media and pharyngitis.
    Microbiology ApplicationsTOKU-E cefpodoxime was used in a study by Lahiri et al. : Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C B-lactamase enzyme.

    Cefepime was used by Correa-Martínez, C. L. et al. as part of a screening panel for rapid detection of ESBL, and AmpC β-Lactamases in Enterobacterales.  Read more here: Rapid Detection of Extended-Spectrum β-Lactamases (ESBL) and AmpC β-Lactamases in Enterobacterales: Development of a Screening Panel Using the MALDI-TOF MS-Based Direct-on-Target Microdroplet Growth Assay. 

     

    Cefpodoxime free acid is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    • Klebsiella pneumoniae 8 µg/mL - 64 µg/mL
    • Haemophilus influenzae 0.032 µg/mL – 1 µg/mL
    • For a complete list of cefpodoxime MIC values, click here.
    Molecular FormulaC15H17N5O6S2
    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

    MICBacteroides bivius| 0.25 - >64|| Bacteroides disiens| 0.25 - >64|| Bacteroides distasonis| 0.25 - >64|| Bacteroides fragilis| 0.25 - 128|| Bacteroides ovatus| 0.25 - >64|| Bacteroides thetaiotaomicron| 0.25 - >64|| Bacteroides vulgatus| 0.25 - >64|| Bordetella pertussis | 8 - 16|| Brucella abortus| 0.25|| Brucella melitensis| 0.25|| Brucella suis| 0.25|| Burkholderia cepacia| 16 - >128|| Citrobacter amalonaticus| 8 - 16|| Citrobacter braakii| >16|| Citrobacter farmeri| 1 - >16|| Citrobacter freundii| 0.5 - >128|| Citrobacter spp.| ≥16|| Citrobacter werkmanii | >16|| Clostridium difficile| ≥64|| Clostridium histolyticum | 0.25 - 16|| Clostridium sordellii| 0.25 - 16|| Clostridium sporogenes| 0.25 - 16|| Enterobacter aerogenes| 0.25 - >64|| Enterobacter amnigenus| >16 || Enterobacter asburiae| >16|| Enterobacter cloacae| 0.03 - >128|| Enterobacter hormaechei| 8 - >16|| Enterobacter intermedius| >16|| Enterobacter sakazakii| 0.13 - 1|| Enterobacter taylorae| >16|| Enterobacteriaceae| 0.06 - 128|| Enterococci| 1 - 128|| Enterococcus faecalis| 1 - >128|| Enterococcus faecium| >64 - ≥128|| Enterococcus liquefaciens | >64|| Escherichia coli| 0.12 - 512|| Haemolytic streptococci| 0.015 - 0.12|| Haemophilus influenzae| ≤0.03 - 1|| Haemophilus parainfluenzae| 0.06 - 0.13|| Haemophilus spp.| 0.06 - 0.5|| Hafnia alvei| 1 - 16|| Helicobacter pylori| 0.5 - 4|| Klebsiella oxytoca (ceftazidime-resistant)| 0.06 - 2|| Klebsiella pneumonia| 0.03 - >128|| Klebsiella rhinoscleromatis| >16|| Listeria innocua| 2 - >64|| Listeria ivanovii| 2 - >64|| Listeria monocytogenes| 2 - >64|| Listeria seeligeri| 2 - >64|| Listeria welshimeri| 2 - >64|| Moraxella catarrhalis| ≤0.03 - >4|| Morganella morganii| 0.125 - 64|| Neisseria gonorrhoeae (penicillin-resistant)| 0.004 - 0.06|| Neisseria spp.| 0.002 - 0.06|| Pneumococci| 0.03 - 4|| Proteus mirabilis| 0.032 - 8|| Proteus penneri| 16 - 32|| Proteus vulgaris| 0.032 - >128|| Providencia rettgeri| ≤0.004 - 8|| Providencia stuartii| 0.06 - >16|| Pseudomonas aeruginosa| >64 - >128|| Pseudomonas cepacia| 4 - >64|| Pseudomonas fluorescens | 8 - >64|| Pseudomonas putida| 8 - >64|| Pseudomonas spp.| 0.25 - 128|| Pseudomonas stutzeri| 8 - >64|| Salmonella Agona| 0.13 - 0.5|| Salmonella Brandenburg| 0.13 - 0.5|| Salmonella Enteritidis| 0.13 - 0.5|| Salmonella typhimurium| 0.13 - 0.5|| Serratia fonticola| >16|| Serratia liquefaciens| 0.25 - >64|| Serratia marcescens| 0.25 - >128|| Serratia plymuthica| 8|| Serratia rubidaea| 2 - 8|| Shigella boydii| 0.25 - 0.5|| Shigella flexneri| 0.25 - 0.5|| Shigella sonnei| 0.25 - 0.5|| Staphylococci| 1 - 128|| Staphylococcus aureus| 1 - >128|| Staphylococcus cohnii| 2 - 8|| Staphylococcus epidermidis| 0.25 - >128|| Staphylococcus haemolyticus | 1 - >64|| Staphylococcus hominis| 0.5 - 2|| Staphylococcus intermedius| 0.5|| Staphylococcus pseudintermedius| 0.25 - 8|| Staphylococcus saprophyticus| 2 - 8|| Staphylococcus simulans| 0.5 - 2|| Staphylococcus warneri| 0.5 - 1|| Stenotrophomonas maltophilia| 0.094 - >128|| Streptococci| 0.008 - 0.5|| Streptococcus agalactiae| 0.032 - 0.063|| Streptococcus milleri (group)| 0.015 - 0.25|| Streptococcus mitior| 0.015 - 0.13|| Streptococcus pneumonia| 0.008 - 16|| Streptococcus pyogenes| ≤0.004 - 2|| Xanthomonas maltophilia| >64|| Yersinia enterocolitica| 0.5 - 2||