SKU: C268  / 
    CAS Number: 606-59-7

    Cinnabarinic acid

    $137.00 - $479.50

    Cinnabarinic acid is an endogenous kynurenine metabolite formed from oxidative dimerization of 3-​hydroxyanthranilic acid and transamination of 3-​hydroxykynurenine. Cinnabarinic acid activates glutamate receptors by interacting with residues of the glutamate binding pocket of mGlu4. Cinnabarinic acid induces apoptosis in T cells through generation of reactive oxygen species, the loss of mitochondrial membrane potential and caspase activation.

    Molecular Formula  C14H8N2O6

    Fazio F et al (2012)  Cinnabarinic Acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol. Pharmacol. 81:643

    Hariamatsu R et al (2008)  Cinnabarinic acid generated from 3-​hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J. Cell Biochem. 103:42

    Zollner H et al (1976)  Effects of cinnabarinic acid on mitochondrial respiration. Biochem. Pharmacol. 2:643