Cinnabarinic acid is an endogenous kynurenine metabolite formed from oxidative dimerization of 3-hydroxyanthranilic acid and transamination of 3-hydroxykynurenine. Cinnabarinic acid activates glutamate receptors by interacting with residues of the glutamate binding pocket of mGlu4. Cinnabarinic acid induces apoptosis in T cells through generation of reactive oxygen species, the loss of mitochondrial membrane potential and caspase activation.
| Molecular Formula | C14H8N2O6 |
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Fazio F et al (2012) Cinnabarinic Acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol. Pharmacol. 81:643 Hariamatsu R et al (2008) Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J. Cell Biochem. 103:42 Zollner H et al (1976) Effects of cinnabarinic acid on mitochondrial respiration. Biochem. Pharmacol. 2:643 |
