Tropodithietic Acid is a potent antibiotic isolated from a Roseobacter strain by Brinkhoff and colleagues at the University of Gottingen, Germany in 2004. Tropodithietic Acid is a strong inhibitor of marine bacteria, promoter of algal health and a potent quorum sensing regulator. Tropodithietic Acid is a tropone that exists as an interconverting tautomer with thiotropocin, itself isolated in the 1980s as a metabolite from a strain of Pseudomonas. Tropodithietic acid has potent, broad-spectrum anticancer activity, acting via a mechanism similar to polyether antibiotics.
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Wilson MZ et la (2016) Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ -glutamyl cycle as a proton sink. Proc. Nat. Acad. Sci. 2016 113:1630