SKU: C073  / 
    CAS Number: 8068-28-8

    Colistin Sodium Methanesulfonate

    RM954.75 - RM7,125.00
    Colistin Sodium Methanesulfonate

    Colistin Sodium Methanesulfonate is considered an inactive prodrug of colistin, which means it is inactive until converted into colistin by cellular enzymes. It is prepared by the reaction of colistin with formaldehyde, followed by sodium bisulfate. It is also less potent and less toxic than colistin sulfate and is effective against Gram-negative bacteria. Colistin works by targeting the bacterial cell membrane, leading to reduced permeability and cell death.  The product is being explored with renewed interest as a possible anti-tuberculosis agent.

    We also offer:

    • Colistin Sulfate, USP (C083)
    • Colistin Sulfate, EP (C039)

     

    Mechanism of Action THe mechamism of action of Colistin Methanesulfonate has not been fully expllored, and has only been described from a histological and genomics perspective.  Researchers used a GCxGC-TOFMS metabolomics approach and found that the prdouct acts by disrupting the cell wall of Mycobacteria.  
    Spectrum Colistin primarily targets and disrupts the cell wall of Gram negative bacteria and Mycobacteria.
    Microbiology Applications Colistin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    • Shigella spp. 64 µg/mL -128 µg/mL
    • Haemophilus influenzae 0.4 µg/mL – 0.8 µg/mL
    • For a complete list of colistin MIC values, click here.
    Molecular Formula C58H115N16Na5O28S5
    References

    Asano T, Kageyama K and Myakumachi (1999) Surface disinfestation of resting spores of Plasmodiophora brassicae used to infect hairy roots of Brassica spp. Phytopathol. 89(4):314-319 PMID 18944777

    Bergen, PJ, Li J, Rayner CR, and Nation RL (2006)  Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa. Antimicrob. Agents Chemother.  50(6): 1953-1958  PMID 16723551

    Falagas ME and Kasiakou SK and Saravolatz LD(2005) Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin. Infect. Dis. 40(9):1333-1341 PMID 15825037

    Koen N, van Breda SV and Loots DT (2018) Elucidating the antimicrobial mechanisms of Colistin Sulfate on Mycobacterium tuberculosis using metabolomics. Tuberculosis 1111:14-19 PMID 30029902

    Koen N, van Breda SV and Loots DT (2018)  Metabolomics of colistin methanesulfonate treated Mycobacterium tuberculosis. Tuberculosis 111:154-160  PMID 30029902

    Komura S, Kurahashi K (1979) Partial purification and properties of L-2,4-diaminobutyric acid activating enzyme from a polymyxin E producing organism. J. Biochem (Tokyo) 86:1013-1021

    Leifert C, Ritchie JY and Waites WM (1991) Contaminants of plant-tissue and cell cultures. World J. Microbiol. Biotechnol. 74):452-469 PMID 24425131

    Mueller MJ, Brodschelm W, Spannagl E and Zenk MH (1993) Signaling in the elicitation process is mediated through the octadecanoid pathway leading to jasmonic acid. Proc. Natl. Acad. Sci. USA Vol. 90(16):7490-7494 PMID 11607420

    Wallace, SJ et al (2012)Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation J. Pharma Sci 101 (9):3347-3359 PMID 22623044

     
    MIC Cunninghamella bertholletiae (5633)| 16 － ?| 1101| Cunninghamella bertholletiae (6694)| 16 － ?| 1101| Cunninghamella bertholletiae (6733)| 32 － ?| 1101| Diplococcus pneumoniae| 400 － >400| 1413| Haemophilus influenzae| 0.4 － 0.8| 1413| Mucor circinelloides (4030)| 16 － ?| 1101| Mucor circinelloides (4480)| 16 － ?| 1101| Mucor circinelloides (4818)| 32 － ?| 1101| Mucor circinelloides (5904)| 16 － ?| 1101| Pseudomonas tabaci| 2 － ?| 1431| Rhizopus bertholletiae (6254)| 16 － ?| 1101| Rhizopus homothallicus (5790)| 16 － ?| 1101| Rhizopus homothallicus (5910)| 32 － ?| 1101| Rhizopus homothallicus (6360)| 32 － ?| 1101| Rhizopus microsporus (6164)| 32 － ?| 1101| Rhizopus oryzae (3140)| 16 － ?| 1101| Rhizopus oryzae (4153)| 16 － ?| 1101| Rhizopus oryzae (4549)| 32 － ?| 1101| Rhizopus oryzae (5496)| 16 － ?| 1101| Rhizopus oryzae (5799)| 8 － ?| 1101| Rhizopus oryzae (5879)| 32 － ?| 1101| Rhizopus oryzae (6093)| 16 － ?| 1101| Rhizopus oryzae (6725)| 16 － ?| 1101| Rhizopus sp. (4523)| 16 － ?| 1101| Treponema hyodysenteriae| >100 － ?| 1427|